Active substance: Doxycycline
The mechanisms responsible for decreased absorption appear to be chelation and an increase in gastric pH. Recent research has shown no significant loss of effectiveness in oral contraceptives while using most tetracycline antibiotics including doxycycline, although many physicians still recommend the use of barrier contraception for people taking the drug to prevent unwanted pregnancy.
Doxycycline crosses into breastmilk. The best available evidence indicates that doxycycline has little or no effect on hypoplasia of dental enamel or on staining of teeth and the CDC recommends the use of doxycycline for treatment of Q fever and also for tick-borne rickettsial diseases in young children and others advocate for its use in malaria.
It works by preventing bacteria from reproducing through the inhibition of protein synthesis. It can also be re-absorbed in the renal tubules and gastrointestinal tract due to its high lipophillicity so has a long elimination half life, and does not accumulate in the kidneys of patients with kidney failure due to the compensatory excretion in faeces.About doxycycline Doxycycline is an antibiotic as chest infections, skin infections, rosacea, dental infections and sexually transmitted infections.
It inhibits the synthesis of bacterial proteins by binding to the 30 S ribosomal subunit, which is only found in bacteria. Carry on for 4 weeks after leaving the area.
Check with your doctor or pharmacist that doxycycline is the best medicine to prevent malaria in the country you are travelling to. Important Carry on taking doxycycline until you've completed the course, even if you feel better.
How to take it Always swallow your doxycycline capsule whole and have it with a full glass of water a medium sized glass - 200 ml. You can take this medicine with or without food.
However you're less likely to feel sick if you have it with food. It's important to take doxycycline while you're in an upright position. You can be sitting, standing or walking. This will stop the medicine irritating your food pipe or stomach.
What if I forget to take it? If you forget to take a dose, take it as soon as you remember, unless it's nearly time for your next dose.
In this case, just leave out the missed dose and take your next dose as normal.
Never take 2 doses at the same time.