Active substance: Doxycycline
Absorption of tetracyclines has been reported to be impaired by milk products, aluminum hydroxide gels, sodium bicarbonate, calcium and magnesium salts, laxatives containing magnesium and iron preparations.
The mechanisms responsible for decreased absorption appear to be chelation and an increase in gastric pH. Recent research has shown no significant loss of effectiveness in oral contraceptives while using most tetracycline antibiotics including doxycycline, although many physicians still recommend the use of barrier contraception for people taking the drug to prevent unwanted pregnancy.
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One randomized controlled trial has assessed in type 2 diabetic patients with no known macrovascular. American Cyanamid was one of these, and in the late 1940 s chemists there discovered chlortetracycline, the first member of the tetracycline class of antibiotics.
Both compounds, like penicillin, were natural products and it was commonly believed that nature had perfected them, and further chemical changes could only degrade their effectiveness.
Scientists at Pfizer led by Lloyd Conover modified these compounds, which led to the invention of tetracycline itself, the first semi-synthetic antibiotic. Information: You can report any suspected side effect to the UK safety scheme.
How to cope with side effects What to do about: headaches - make sure you rest and drink plenty of fluids.
Everyday painkillers, such as paracetamol and ibuprofen, are safe to take with doxycycline. It might help to take your doxycycline after a meal or snack but avoid dairy products like milk, cheese and yoghurt.
Dairy products can stop your body absorbing your medicine properly.
If you are being sick, drink plenty of fluids, such as water or squash, to avoid dehydration. Signs of dehydration include peeing less than usual or having strong-smelling pee.
Do not take any medicines to treat vomiting without speaking to a pharmacist or doctor.