Active substance: Gabapentin
Galliprant was approved by the FDA in to treat pain and inflammation in dogs with osteoarthritis.
It can be used by dogs unable to tolerate other types of NSAIDs, including dogs with liver and kidney disease. These risks include clinical signs associated with gastrointestinal toxicity such as vomiting, diarrhea, decreased appetite, and decreasing albumin and total protein.
Product insert: The most common side effects associated with Galliprant include vomiting, soft, mucoid stools, diarrhea and decreased appetite.
Concurrent use with other anti-inflammatory drugs has not been studied. Certain dogs, particularly those from herding breeds, have a genetic mutation called MDR 1 that causes sensitivity to ivermectin and many other drugs.
There is no information available about Galliprant's effect on dogs with the MDR 1 mutation, so it should be used with great caution in these dogs.
See Dogs with a Drug Problem for more information. All of them can cause gastric upset and ulceration. Giving with food can help to prevent stomach upset, but not ulceration. It is safest to do blood work before starting any NSAID, and about two weeks after starting, to be sure that it is not affecting the liver or kidneys.
If you use these drugs long term, you should continue to monitor blood work at least every six months to a year more often if problems are suspected or more likely due to the health status of the dog.
Note that COX-2 selective drugs are newer, and were expected to be safer, as they reduce the risk of gastric ulceration, but they can still cause other side effects, including liver and kidney failure. Never combine NSAIDs including aspirin with each other, or with prednisone, as the risk of gastric ulceration is greatly increased.
Note that aspirin accelerates destruction of cartilage, and so is not a good choice for long-term use.
It is also a potent blood thinner. See Giving Your Dog Aspirin for more info.