Active substance: Norfloxacin
According to another embodiment, the compound is a pharmaceutically acceptable acid addition salt.
In some embodiments, acids commonly employed to form pharmaceutically acceptable salts of the compounds of Formulae I, Ia, Ib, Ic, IV, II, and III include inorganic acids such as hydrogen bisulfide, hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid and phosphoric acid, as well as organic acids such as para-toluenesulfonic acid, salicylic acid, tartaric acid, bitartaric acid, ascorbic acid, maleic acid, besylic acid, fumaric acid, gluconic acid, glucuronic acid, formic acid, glutamic acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, lactic acid, oxalic acid, para-bromophenylsulfonic acid, carbonic acid, succinic acid, citric acid, benzoic acid and acetic acid, as well as related inorganic and organic acids.
In one embodiment, pharmaceutically acceptable acid addition salts include those formed with mineral acids such as hydrochloric acid and hydrobromic acid, and especially those formed with organic acids such as maleic acid.
In some cases, compounds as provided herein are commercially available. The person skilled in the art knows how to select and implement appropriate synthetic routes.
Science of Synthesis, Vols.
Wiley,; Trost et al. The reactions for preparing the compounds provided herein can be carried out in suitable solvents which can be readily selected by one of skill in the art of organic synthesis.
Suitable solvents can be substantially non-reactive with the starting materials reactants, the intermediates, or products at the temperatures at which the reactions are carried out.
A given reaction can be carried out in one solvent or a mixture of more than one solvent. Depending on the particular reaction step, suitable solvents for a particular reaction step can be selected by the skilled artisan. Preparation of the compounds provided herein can involve the protection and deprotection of various chemical groups.
The need for protection and deprotection, and the selection of appropriate protecting groups, can be readily determined by one skilled in the art.
The chemistry of protecting groups can be found, for example, in P. Wuts and T. The compound of Formula Ia can be synthesized according to the methods and procedures described, for example, in U.
The compound of Formula Ib can be synthesized according to the methods and procedures described, for example, in U.
The compound of Formula Ic can be synthesized according to the methods and procedures described, for example, in U.