Active substance: Orlistat
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They concluded: The incidence of acute liver injury was higher in the periods both immediately before and immediately after the start of orlistat treatment. Long-term Despite a higher incidence of breast cancer amongst those taking orlistat in early, pooled clinical trial data—the analysis of which delayed FDA review of orlistat —a two-year study published in 1999 found similar rates between orlistat and placebo 0.
A multivitamin tablet containing vitamins A, D, K, and beta-carotene should be taken once a day, at bedtime, when using orlistat. When lipase activity is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, and instead are excreted unchanged.