Active substance: Azithromycin
Despite the recognition of G. This paper will review the agents currently used for the treatment of giardiasis.
The history, mechanism of action, in vitro and clinical studies, and adverse effects are detailed for each drug class. In addition, special clinical situations are discussed and recommendations for therapy are made.
The cyst is the infectious form and is ingested in contaminated water or food or directly from fecal-oral contact. After ingestion, excystation occurs.
Excystation is thought to be initiated by contact with acidic gastric contents, followed by a highly coordinated sequence of events leading to the release of one or two trophozoites 27, 109, 210.
Azithromycin mass treatment exposure was significantly associated with increased odds of carriage of isolates resistant to erythromycin OR 3. The potential linkage between resistance and virulence in E. Keywords: antibiotic resistance, diarrheagenic E.
Approximately half of these deaths occur in sub-Saharan Africa. Although great strides have been made in reducing mortality, due in part to implementation of oral rehydration therapy and appropriate feeding practices during illness, enteric infections are still a significant cause of morbidity worldwide Fischer Walker et al.
The burden is heaviest on pre-school age children who suffer growth faltering and delayed cognitive development Niehaus et al.
Collectively, diarrheagenic Escherichia coli DEC are among the most the most frequently identified causes of both acute and moderate-to-severe diarrhea in both community and clinical settings in low income countries Kotloff et al. DEC are identified by specific virulence factors capable of causing a broad array of gastrointestinal illness.